天津大学教师个人主页系统 黄金海 首页 中文主页 (2023)

黄金海,男,博士,博士生导师,天津大学生命科学学院教授。

邮箱:jinhaih@tju.edu.cn, 地址:Building 15, Rm 216, Tianjin University;

中国医药生物技术协会临床前评价技术委员会、中国禽病学会理事,天津市畜牧兽医协会常务理事,天津市重大动物疫病控制专家组成员,天津市创新人才推进计划重点领域——动物诊疗智造创新团队负责人。长期从事分子病原学及其免疫学研究,先后主持、参与国家自然基金、国家973863、天津市自然基金、国家重点研发计划、天津市研究基础及前沿技术重点项目、天津市支撑重点及横向合作项目等30余项。先后获省市级科技进步一、二、三等奖4项,厅局级科技进步一等奖3项,二等奖1项。已发表论文180余篇,主、参编《分子生物学基本原理及应用实践研究》、《免疫学》等教材及著作9部。

研究方向免疫生物学;分子病原学与免疫学,微生物合成生物学

Researcher IDB-1334-2016, http://www.researcherid.com/rid/B-1334-2016

ORCID: http://orcid.org/0000-0002-1073-533X

研究方向

(1)免疫生物学 新型免疫细胞及其标志分子的挖掘及功能研究;先天性免疫调控分子回路的设计及细胞通路重塑;受体靶向型天然及人工佐剂分子的设计及其调控机制

天津大学教师个人主页系统 黄金海 首页 中文主页 (1)

天津大学教师个人主页系统 黄金海 首页 中文主页 (2)

(2)微生物合成生物学 益生菌设计、工程化建造、代谢调控机制及健康重塑机制;资源微生物基因组大尺度改造重建技术;基于工程化酵母、噬菌体、乳酸菌的口服黏膜疫苗研发;预测疫苗学及新型疫苗的设计与智造技术;高通量抗体库的工程化构建、高通量筛选及应用开发技术。

天津大学教师个人主页系统 黄金海 首页 中文主页 (3)

天津大学教师个人主页系统 黄金海 首页 中文主页 (4)

(3)病原致病及免疫机理研究 病毒免疫逃逸的先天性免疫机制研究;病毒快速拯救及工程化疫苗研发;病毒致病及抗感染免疫的分子机制。

天津大学教师个人主页系统 黄金海 首页 中文主页 (5)

Selected papers

lRuiqi Sun, Yanyu Guo, Xiaoyang Li, Ruiqiao Li, Jingxuan Shi, Zheng Tan, Lilin Zhang, Lei Zhang,Jun Han*,Jinhai Huang*PRRSV Non-Structural Proteins Orchestrate Porcine E3 Ubiquitin Ligase RNF122 to Promote PRRSV Proliferation. Viruses 2022, 14, 424.v14020424.

lHongwei Cao, Deping Hua, Han Zhang, Huixia Zhang, Na Liu, Zhehan Feng, Huliang Li, Baiping Zhao, Lilin Zhang, Yanyu Guo,Jinhai Huang *, Lei ZhangOral immunization of recombinant Saccharomyces cerevisiae expressing fiber-2 of fowl adenovirus serotype 4 induces protective immunity against homologous infection.Veterinary Microbiology271 (2022) 109490.

lLilin Zhang, Lan Yao, Yanyu Guo, Xiaoyang Li, Li Ma, Ruiqi Sun, Xueqing Han, Jing Liu*,Jinhai Huang*, Oral SARS-CoV-2 Spike ProteinRecombinant Yeast CandidatePrompts Specific Antibody and GutMicrobiota Reconstruction in Mice.Frontiers in Microbiology|2022, Vol 13. 792532

l Yinna Song1#, Yanyu Guo1#, Xiaoyang Li#, Ruiqi Sun, Min Zhu, Jingxuan Shi,Zhen Tan, Lilin Zhang*, Jinhai Huang*RBM39 alters phosphorylation of c-Jun and binds to viral RNA to promote PRRSV proliferation.Frontiers in Immunology, 2021.12.1-15.

l Zhe Sun#,Jinhai Huang#, Linjia Su, Jing Li, Fangzheng Qi, Huishan Su, Yanan Chen, Qing Zhang, Qiangzhe Zhang, Zongjin Li, Sihe Zhang, Arf6-mediated macropinocytosis-enhanced suicide gene therapy of C16TAB-condensed Tat/ pDNA nanoparticles in ovarian cancer.Nanoscale, 2021.1-14.

l Hui Zhai#, Jingxuan Shi#, Ruiqi Sun, Zheng Tan, Umm E Swaiba, Wanqing Li, Lilin Zhang, Lei ZhangYanyu Guo*,Jinhai Huang*The Superposition Anti-viral Activity of Porcine Tri-subtype Interferon Expressed by Saccharomyces cerevisiae.Veterinary microbiology.2021

l Min Zhu#, Xiaoyang Li#, Yinna Song, Peidian Shi, Aiping Cao, Lilin Zhang,yanyu Guo*, Jinhai Huang*, The C/EBPβ-Dependent Induction of TFDP2 Facilitates Porcine Reproductive and Respiratory Syndrome Virus Proliferation.Virologica Sinica, 2021.6,1-11.

l Jingxuan Shi #, Heng Chi#, Aiping Cao, Min Zhu, Linlin Zhang, Fuzhou Xu*,Jinhai Huang*Development of IMBs-qPCR Detection Method for Yersinia enterocolitica Based on the foxA Gene.Archives of Microbiology.2021, 1-10.

l Xiaoyang Li#, Yanyu Guo#, Yinna Song#, Ruiqi Sun, Min Zhu, Zheng Tan, Umm E Swaiba, Lilin Zhang,Jinhai Huang*,The Glycosyltransferase ST3GAL2 Modulate the Proliferation and Inflammation Response in PRRSV InfectionArchives of Virology, 2021,1-10.

l Chen Chen#, Deping Hua#, Jingxuan Shi, Zheng Tan, Min Zhu, Kun Tan, Lilin Zhang,Jinhai Huang*Porcine immunoglobulin Fc fused P30/P54 protein of African swine fever virus displaying on surface of S. cerevisiae elicit strong antibody production in swine.Virologica Sinica,2021;36 (2):207-219.

l Min Zhu, Heng Chi, Xiaoyang Li, Yinna Song, Jingxuan Shi, Jiashun Wang,Jinhai Huang*, The dUTPase of caprine arthritis encephalitis virus negatively regulates interferon signaling pathway,Archives of microbiology, 2021

l Aiping Cao, Heng Chi, Jingxuan Shi ,Ruiqi Sun, Kang Du, Yinna Song,Min Zhu, Lilin Zhang,Jinhai Huang* Visual detection of Clostridium perfringens alpha toxin by combining nanometer microspheres with smart phones.Microorganisms2020,8 (12),1865.

l Jiaqi Wu#, HengChi#, Yanyu Guo, Aiping Cao, Jingxuan Shi, Min Zhu, Lilin Zhang, DepingHua*,Jinhai Huang*, Antiviral Protein Viperin Modulate N protein to Inhibit Porcine Epidemic Diarrhea Virus proliferation.Archives of Virology,2020, 165:2279–2289

l Peidian Shi, Yanyu Guo, Yanxin Su, Min Zhu, Yali Fu, Heng Chi, Jiaqi Wu,Jinhai Huang*SUMOylation of DDX39A alters binding & export of antiviral transcripts to control innate immunity.Journal of Immunology, 2020, 205(1):168-180.

l Yanyu Guo, Ruiqiao Li, Zheng Tan, Jingxuan Shi, Yali Fu, Yinna Song, Min Zhu, Lei Zhang,Jinhai Huang*E3 ubiquitin ligase ASB8 negatively regulates interferon via regulating TBK1/IKKi homeostasis.Molecular Immunology. 2020,121, 195-203.

l Yali Fu, Dong Lu,· Yanxin Su,, Heng Chi, Jiashun Wang,Jinhai Huang*Vif Protein of Caprine Arthritis Encephalitis Virus Inhibits Interferon Production,Archives of Virology. 2020, 1-11.

l Xiao Xiao,Wentao Zhang, Deping Hua, Lilin Zhang, Wei Meng,Jinhai Huang*, Lei Zhang*, Cold-inducible RNA-binding protein (CIRBP) promotes porcine reproductive and respiratory syndrome virus (PRRSV)-induced inflammatory response.International Immunopharmacology. 2020,86:106728.

l Ruiqiao Li#, Chen Chen#, Jing He, Lilin Zhang, Lei Zhang, Yanyu Guo,Jinhai Huang*, E3 Ligase ASB8 Promotes PRRSV Proliferation and Function via Stabilizing of Nsp 1α and Degrading of IKK.Virology, 201953255–68.

l Xiao Xiao,Wentao Zhang, Deping Hua, Lilin Zhang, Wei Meng,Jinhai Huang*, Lei Zhang*, Cold-inducible RNA-binding protein (CIRBP) promotes porcine reproductive and respiratory syndrome virus (PRRSV)-induced inflammatory response.International Immunopharmacology.2020, 86:106728.

l Chengxue Zhao#, Chen Chen#, Ying Li, Shuren Dong, Kun Tan,,Yuhui Tian,,Lilin Zhang,Jinhai Huang*, Lei Zhang*, Genomic characterization of a novel recombinant porcine astrovirus isolated in northeastern China.Archives of Virology, 2019, 164(3): 1469-1473.

l Peidian shi#; Yanxin Su#; Yi Li#; Lilin Zhang; Dong Lu; Ruiqiao Li; Lei Zhang;Jinhai Huang*The alternatively spliced porcine FcγRI regulated PRRSV-ADE infection and proinflammatory cytokine production.Developmental and Comparative Immunology, 2019, 90: 186~196.

l Peidian Shi1#, Yanxin Su1#, Ruiqiao Li1, Zhixuan Liang, Shuren Dong,Jinhai Huang*PEDV nsp16 negatively regulates innate immunity to promote viral proliferation. Virus Research, 2019, 26557–66.

l Yanxin Su(#); Peidian Shi(#); Lilin Zhang; Dong Lu; Chengxue Zhao; Ruiqiao Li; Lei Zhang*;Jinhai Huang*,The Superimposed Deubiquitination Effect of OTULIN and PRRSV Nsp11 Promoted the Multiplication of PRRSV.Journal of Virology, 2018.2.12, 92(9): 1-17.

l Peidian Shi(#); Yanxin Su(#); Ruiqiao Li; Lei Zhang; Chen Chen; Lilin Zhang; Kay Faaberg*;Jinhai Huang*, Dual Regulation of Host TRAIP Post-translation and Nuclear/Plasma Distribution by Porcine Reproductive and Respiratory Syndrome Virus Non-structural Protein 1a Promotes Viral Proliferation.Frontiers in Immunology, 2018.12.6, 9(3023): 1~18.

l Peidian Shi(#); Lilin Zhang(#); Jiashun Wang(#); Dong Lu; Yi Li; Jie Ren; Menglu Shen; Lei Zhang;Jinhai Huang*, Porcine FceRI Mediates Porcine Reproductive and Respiratory Syndrome Virus Multiplication and Regulates the Inflammatory Reaction.Virologica Sinica(2018) 33:249–260.

l Chen Pei(#); Zhang Lei(#); Chang Na; Shi Peidian; Gao Tian; Zhang Lilin*, Huang Jinhai*, Preparation of virus-like particles for porcine circovirus type 2 by YeastFab Assembly.Virus Genes,2018.4, 54(2): 246~255.

l Lei Zhang#; Jie Ren#; Peidian Shi; Dong Lu; Chengxue Zhao; Yanxin Su; Lilin Zhang;Jinhai Huang*, The Immunological Regulation Roles of Porcine b-1, 4 Galactosyltransferase V (B4GALT5) in PRRSV Infection.Frontiers in Cellular and Infection Microbiology,2018.2.9, 8(48): 1~13.

l Ruiqiao Li,Xuefeng Qi,Xueying Han,Caihong Liu,Jing Wang, Ruichun Wang, Jingyu Wang*,Jinhai Huang*,Deterioration of eggshell quality is related to calbindin in laying hens infected with velogenic genotype VIId Newcastle disease virus.Theriogenology.2017,91(3):62-68. IF: 2.288, Q1, 26/142.

l Yi Li, Hui Deng, Pei-Dian Shi, Dan-Dan Xu, Li-Lin Zhang, Lei Zhang*,Jinhai Huang* , Toxic effects of seu are different from those of other staphylococcal enterotoxins.American Journal of Translational Research. 2017, 9(4):1618-1629.

l Jiashun Wang#, Yi Li1#, Hui Deng, Jia Chen, Ying Li, Zhixuan Liang, Deping Hua,Jinhai Huang*. Rapid detection of food-borneSalmonellacontamination using IMBs-qPCR method based onpagCgene.Brazilian Journal of Microbiology, 2017.10:3241-9.

l Menglu Shen, Yi Li, Linlin Zhang, Songbao Dai, Jiashun Wang, Yongqing Li, Lei Zhang*,Jinhai Huang*Staphylococcal enterotoxin Profile of China Isolates and the Superantigenicity of Some Novel EnterotoxinsArchives of Microbiology.2017, 199: 1-14.

l Ruiqiao Li,† Lilin Zhang,† Peidian Shi, Hui Deng, Yi Li, Jie Ren, Xubin Fu, Lei Zhang*,Jinhai HuangImmunological Effects of Different Types of Synthetic CpG Oligodeoxynucleotides on Porcine Cells. RSC advances .2017, 7, 43289-99.

l Hongzhi Kang, Hui Deng, Menglu Shen, Xianzhi He, Yi Li,Yihe xia, Hongjun Wang, Zhixuan Liang,Jinhai Huang* Superantigenicity analysis of Staphylococcal Enterotoxins SElK and SElQ in a mouse model.RSC advances.2015.5, 29684–29692.

l Qiangzhe Zhang, Caihong Zhang, Mengxu Gao, Xianzhi He, Yinghua Diao, Sagar M Goyal, Sunil K. Mor,Jinhai Huang*, Evolutionary, epidemiological, demographical, and geographical dissection of porcine bocavirus in China and America.Virus Research. 2015,195 (1): 13–24.

l Shiwen Zhuang, Junshu Fu,Chris Powell,Jinhai Huang*, Yihe Xia, Ruixiang Yan, Production of medium-chain volatile flavour esters inPichia pastoriswhole-cell biocatalysts with extracellular expression of Saccharomyces cerevisiae acyl-CoA:ethanol O-acyltransferase Eht1 or Eeb1.SpringerPlus, 2015, 4:467-476.

l Xianzhi He, Lei Zhang, Pengchong Liu, Li Liu, Hu Deng,Jinhai Huang*, Construction and Characterization of VL-VH Tail-parallel Genetically Engineered Antibodies against Staphylococcal Enterotoxins.Immunologic Research.2015,61(3): 281-293.

l Jianming Wu, Rui Lin, Jinhai Huang, Weihua Guan, William S. Oetting, P. Sriramarao, Malcolm N. Blumenthal, Functional Fcgamma Receptor Polymorphisms Are Associated with Human Allergy. PLOS ONE,2014,Vol 9(2): e89196.

l Jia Chen, Xianzhi He,Jinhai Huang*,Diet effects in gut microbiome and obesity, Journal of Food Science. 2014Vol 794: 442–451.

l Mengmeng Liu, Yi Li,Yihe Xia,Jinhai Huang*,Lili Guo, Detection and genetic analysis of Porcine Bocavirus in different swine herds in North Central China.The world science journal.2014947084.

l Jinhai Huang, Sunil K. Mor, Jonathan Erber, Elyce Voss, Sagar M. Goyal,Detection and characterization of porcine bocavirus in United States.Archives of Virology, 2014,159 (7):1797-1801.

l Jinhai Huang,Yi Li, Mengmeng Liu, Yihe Xia, Zhirong Li, A Novel Subgenotype of Torque teno Virus 1 (TTSuV1) in Slaughter Pigs in China.Food and environmental virology. 2013,226-230.

l Xu Cong,Junfeng Jiang,Tiegen Liu, Kun Liu,Pengchong Liu,Jinhai Huang,Qiang Ji,Yimo Zhang, Characterization of immobileization of staphylococcal enterotoxin an antibody on microtube.Sensor Letters, 2012, Vol 10:1523-1527.

l Yi Li, Fengjuan Zhou, Xia Li, Jianhua Wang, Xiangping Zhao,Jinhai Huang*Development of TaqMan-based qPCR method for detection of caprine arthritis-encephalitis virus (CAEV) infection.Archives of Virology, 2013158:2135-2141.

l Jin-Hai Huang,Yue-Hui Sun,Yebing Liu,Huazhi Xiao,Shiwen ZhuangDevelopment of a loop-mediated isothermal amplification method for rapid detection of Caprine arthritis encephalitis virus proviral DNA.Archives of Virology, 2012. 1578:1463-1469.

l Jianming Wu, Maureen Richards; Jinhai Huang; Lena Al-Harthi; Xiulong Xu; Rui Lin; Fenglong Xie; Andrew W. Gibson; Jeffrey C. Edberg; Robert P. Kimberly. Human, FasL Gene is a Target of β-catenin/T-cell Factor Pathway and Complex FasL Haplotypes Alter Promoter Functions".PLoS ONE,2011Vol 610):e26143.

l Han XueqingLin XiangmeiLiu BohuaHou Yihong,Huang Jinhaiet alSimultaneously subtyping of all influenza A viruses using DNA microarraysJournal of Virological Methods2008152(1-2)117–121.

· China/ZL201110049950.X: The real-time PCR method to differentiating classic and high virulent strains of porcine reproductive and respiratory syndrome virus.

· China/ZL200710064255.4: Gene chips for detection and genotyping of avian influenza viruses.

· China/ ZL2006100894635: aGST-ELISA method to detect avian influenza virus antibodies.

· China/ ZL200620027159.3: A new lamb incubator.

· China/ ZL200620027282.5: A sponge pessary implant device used for goats.

· China/ ZL200620027751.3: A device with light for dairy vagina detection.

· China/ ZL200620027281.0: A calf raising bed.

Selected Published Books

· Huang Jinhai(chief editor), Principles of Molecular Biology & Practical Application. China Atomic Press.2015.12

· Changxin Wu,et.al., 10000 Selected Problems in Sciences—Agriculture Ssciences.China Science Press.2011.

· Wang Jiaxin, Qin Aijian,Huang Jinhai,et. al., Immunology, China Agriculture Press.2009.

· Diao Enjie, Xu Baocheng,Huang Jinhai.et. al., Food Safety and Quality Management.Chemistry Industry Press.2008.

· Li Zhirong, Ding Shuangyang,Huang Jinhai.et. al., Detection Techniques of Veterinary Drug Residues.Tianjin Science and Technology Press.2008.

· Shi Zhicheng, Wang Jianhua,Huang Jinhai.et. al., Animal Toxiology,China Agriculture Press.2002.

Research Projects

· “Biosythesis of Key proteins used in veterinary medicine”(TSBICIP-KJGG-014)supported by Synthetic biotechnology innovation capability improvement project.

· R&D of multi-valent avian influenza vaccine based onSaccharomyces cerevisiaechassis”(20YFZCSN00340)., supported by underprop project of Tianjin Science and Technology committee in Tianjin,China.

· “Molecular mechanism of multisystem inflammation syndrome caused by staphylococcal enterotoxins”supported by National Science Fund in China (31272540

· “Study on the virus-like particle vaccine of porcine circovirus type 2 usingself-designedS. cerevisiaesystem”, supportedby underprop project of Tianjin Science and Technology committee in Tianjin (16YFZCNC00640)

· “ Techniques of cell suspension culture in animal vaccine preparation”, Tianjin science and technology support key project plan(13ZCZDNC08800)

· “ Immobiltzation of Recombinant Chitinase with Magnetic Carrier and Analysis on Structure and Effect”(31101362)supported by National Science Fund in China

· “Development of genotyping method and high-output detection kits of staphylococcal enterotoxins in food”(08JCZDJC22600), supported by a grant from the application basement & advanced technology project of Tianjin Science and Technology committee in Tianjin ,China.

· “R&D of a recombinant of porcine antimicrobial Peptide”(07ZCKFNC00600)., supported by underprop project of Tianjin Science and Technology committee in Tianjin,China.

· “Study on pathogen variation and control measure of procine productive and respiratory syndrome in Tianjin region ”(08JCZDJC22900), supported by a grant from the application basement & advanced technology project of Tianjin Science and Technology committeein Tianjin ,China.

· “Molecular mechanisms of immune response of goats infected with caprine arthritis encephalitis virus”supported by national Science fund (30771613) in China.

· “Research on the protein-chip for diagnosis of some important bovine infectious diseases”, 06YFGZSH02100, supported byTianjin Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China.

· “Study on of the molecular diagnosis kits for diagnosis of caprine arthritis encephalitis virus ”supported by General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China.

· “Construction of recombinant plasmid of chicken Marek's disease virus and preparation of major protective antigen protein”, 2013GKF-0482, Beijing academy of agriculture science.

· “Rapid detection of Foot and mouth disease virus, avian influenza virus by Helicase-dependent Isothermal DNA Amplification(HAD) techniques”, 2009IK021,Beijing Administration of Quality Supervision, inspection and Quarantine of the People's Republic of China.

· “Diagnosis & control key techniques of animal epidemic diseases”, a collaboration plan of foreign expert, supported by Tianjin government.

Reviewer for

PLOS pathogens; Frontiers in Immunology; Journal of VirologyJournal of Agriculture and Food Chemistry; Veterinary Microbiology; Virologica Sinica; Frontiers in Microbiology; Archives of Virology; Journal of virological methods; BMC Complementary and Alternative Medicine; Journal of Veterinary Science & Technology; Journal of food safety

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